Mechanobiology of Cells

We study the cellular mechanics of using different techniques. Static properties are probed with micropipet aspiration or capilary micromechanics. We also employ AFM. The dynamic, viscoelastic fingerprint of cells is for example addressed by the interaction of cells with hydrodynamic or acoustic fields. We exploit the mechano-elastic response of cells in different applications such as cell sorting and diagnosis.



Geislinger, T. M., and Franke, T. (2014) Hydrodynamic lift of vesicles and red blood cells in flow — from Fåhræus & Lindqvist to microfluidic cell sorting. Advances in Colloid and Interface Science, 208, pp. 161-176. (doi:10.1016/j.cis.2014.03.002)

Geislinger, T.M., and Franke, T. (2014) Filtern war gestern: Sortierung von zirkulierenden Tumorzellen in Lab-on-a-Chip Systemen. GIT Labor-Fachzeitschrift, 4, pp. 50-52.

Geislinger, T. M., Chan, S., Moll, K., Wixforth, A., Wahlgren, M., and Franke, T. (2014) Label-free microfluidic enrichment of ring-stage Plasmodium falciparum-infected red blood cells using non-inertial hydrodynamic lift. Malaria Journal, 13(1), p. 375. (doi:10.1186/1475-2875-13-375)

Geislinger, T. M., and Franke, T. (2013) Sorting of circulating tumor cells (MV3-melanoma) and red blood cells using non-inertial lift. Biomicrofluidics, 7(4), 044120. (doi:10.1063/1.4818907)

Geislinger, T.M., Eggart, B., Braunmüller, S., Schmid, L., and Franke, T. (2012) Separation of blood cells using hydrodynamic lift. Applied Physics Letters, 100(18), p. 183701. (doi:10.1063/1.4709614)


Hydrodynamic deformation

Noguchi, H., Gompper, G., Schmid, L., Wixforth, A., and Franke, T. (2010) Dynamics of fluid vesicles in flow through structured microchannels. Europhysics Letters, 89(2), p. 28002. (doi:10.1209/0295-5075/89/28002)

Braunmüller, S., Schmid, L., Sackmann, E., and Franke, T. (2012) Hydrodynamic deformation reveals two coupled modes/time scales of red blood cell relaxation. Soft Matter, 8(44), p. 11240. (doi:10.1039/C2SM26513C)

Braunmüller, S., Schmid, L., and Franke, T. (2011) Dynamics of red blood cells and vesicles in microchannels of oscillating width. Journal of Physics: Condensed Matter, 23(18), p. 184116. (doi:10.1088/0953-8984/23/18/184116)

Franke, T., Hoppe, R. H. W., Linsenmann, C., Schmid, L., Willbold, C., and Wixforth, A. (2011) Numerical simulation of the motion of red blood cells and vesicles in microfluidic flows. Computing and Visualization in Science, 14(4), pp. 167-180. (doi:10.1007/s00791-012-0172-1)



Forsyth, A. M., Braunmüller, S., Wan, J., Franke, T., and Stone, H. A. (2012) The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release. Microvascular Research, 83(3), pp. 347-351. (doi:10.1016/j.mvr.2012.02.004)

Wyss, H. M., Franke, T., Mele, E., and Weitz, D. A. (2010) Capillary micromechanics: measuring the elasticity of microscopic soft objects. Soft Matter, 6(18), pp. 4550-4555. (doi:10.1039/C003344H)

Lipowsky, R., Brinkmann, M., Dimova, R., Franke, T., Kierfeld, J., and Zhang, X. (2005) Droplets, bubbles, and vesicles at chemically structured surfaces. Journal of Physics: Condensed Matter, 17(9), S537-S558. (doi:10.1088/0953-8984/17/9/015)