{"id":63,"date":"2015-10-16T00:06:26","date_gmt":"2015-10-16T00:06:26","guid":{"rendered":"http:\/\/frankelab.de\/?p=63"},"modified":"2015-10-16T13:31:55","modified_gmt":"2015-10-16T13:31:55","slug":"microfluidic-on-chip-diagnostics","status":"publish","type":"post","link":"https:\/\/frankelab.de\/?p=63","title":{"rendered":"On Chip Diagnostics"},"content":{"rendered":"

We employ microfluidic and acoustic techniques to select, enrich and sort biological cells.<\/p>\n

<\/p>\n
\n\"RBCs
RBCs driven through a microchannel by acoustic actuation mimicking a heartbeat-like pressure profile<\/figcaption><\/figure>\n

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 <\/p>\n

SAW-Actuated Circular Flow Chamber<\/h3>\n

Schmid, L., Wixforth, A., Weitz, D. A., and\u00a0Franke, T.\u00a0(2012)\u00a0Novel surface acoustic wave (SAW)-driven closed PDMS flow chamber.\u00a0Microfluidics and Nanofluidics<\/i>, 12(1-4), pp. 229-235. (doi:10.1007\/s10404-011-0867-5)<\/a><\/p>\n

 <\/p>\n

Non-Inertial-Lift<\/h3>\n

Geislinger, T. M., and\u00a0Franke, T.\u00a0(2014)\u00a0Hydrodynamic lift of vesicles and red blood cells in flow \u2014 from F\u00e5hr\u00e6us & Lindqvist to microfluidic cell sorting.\u00a0Advances in Colloid and Interface Science<\/i>, 208, pp. 161-176. (doi:10.1016\/j.cis.2014.03.002)<\/a><\/p>\n

Geislinger, T.M., and\u00a0Franke, T.\u00a0(2014)\u00a0Filtern war gestern: Sortierung von zirkulierenden Tumorzellen in Lab-on-a-Chip Systemen.\u00a0GIT Labor-Fachzeitschrift<\/i>, 4, pp. 50-52.<\/a><\/p>\n

Geislinger, T. M., Chan, S., Moll, K., Wixforth, A., Wahlgren, M., and\u00a0Franke, T.\u00a0(2014)\u00a0Label-free microfluidic enrichment of ring-stage Plasmodium falciparum-infected red blood cells using non-inertial hydrodynamic lift.\u00a0Malaria Journal<\/i>, 13(1), p. 375. (doi:10.1186\/1475-2875-13-375)<\/a><\/p>\n

Geislinger, T. M., and\u00a0Franke, T.\u00a0(2013)\u00a0Sorting of circulating tumor cells (MV3-melanoma) and red blood cells using non-inertial lift.\u00a0Biomicrofluidics<\/i>, 7(4), 044120. (doi:10.1063\/1.4818907)<\/a><\/p>\n

Geislinger, T.M., Eggart, B., Braunm\u00fcller, S.,\u00a0Schmid, L., and\u00a0Franke, T.\u00a0(2012)\u00a0Separation of blood cells using hydrodynamic lift.\u00a0Applied Physics Letters<\/i>, 100(18), p. 183701. (doi:10.1063\/1.4709614)<\/a><\/p>\n

others<\/h3>\n

Forsyth, A. M., Braunm\u00fcller, S., Wan, J., Franke, T., and Stone, H. A. (2012) The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release. Microvascular Research, 83(3), pp. 347-351. (doi:10.1016\/j.mvr.2012.02.004) <\/a><\/p>\n

Issadore, D., Franke, T., Brown, K. A., and Westervelt, R. M. (2010) A microfluidic microprocessor: controlling biomimetic containers and cells using hybrid integrated circuit\/microfluidic chips. Lab on a Chip, 10(21), pp. 2937-2943. (doi:10.1039\/C0LC00092B) <\/a><\/p>\n

Kerleta, V., Andrlik, I., Braunm\u00fcller, S., Franke, T., Wirth, M., and Gabor, F. (2010) Poloxamer 188 supplemented culture medium increases the vitality of Caco-2 cells after subcultivation and freeze\/thaw cycles. Alternatives to Animal Experimentation, 27(3), pp. 191-197. <\/a><\/p>\n

Issadore, D., Franke, T., Brown, K. A., Hunt, T. P., and Westervelt, R. M. (2009) High-voltage dielectrophoretic and magnetophoretic hybrid integrated circuit\/microfluidic chip. Journal of Microelectromechanical Systems, 18(6), pp. 1220-1225. (doi:10.1109\/JMEMS.2009.2030422) <\/a><\/p>\n

Kerleta, V., Andrlik, I., Schneider, M., Franke, T., Wirth, M., and Gabor, F. (2009) Pluronic\u00ae F-68 enhances the nanoparticle-cell interaction. Scientia Pharmaceutica, 77(1), p. 179. (doi:10.3797\/scipharm.oephg.21.SL-12) <\/a><\/p>\n

Franke, T. A., and Wixforth, A. (2008) Microfluidics for miniaturized laboratories on a chip. ChemPhysChem, 9(15), pp. 2140-2156. (doi:10.1002\/cphc.200800349) <\/a><\/p>\n

Franke, T., and Wixforth, A. (2007) Das Labor auf dem Chip: Mikrofluidik. Physik in unserer Zeit, 38(2), pp. 88-94. (doi:10.1002\/piuz.200601126) <\/a><\/p>\n

Thalhammer, S., von Guttenberg, Z., Koehler, U., Zink, A., Heckl, W., Franke, T., Paretzke, H., and Wixforth, A. (2007) Programmierbares, zytogenetisches Submikroliter Chiplabor f\u00fcr molecular-diagnostische Anwendungen. GenomXPress, 2007(1), pp. 29-31.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

We employ microfluidic and acoustic techniques to select, enrich and sort biological cells. RBCs driven through a microchannel by acoustic actuation mimicking a heartbeat-like pressure profile   SAW-Actuated Circular Flow Chamber Schmid, L., Wixforth, A., Weitz, D. A., and\u00a0Franke, T.\u00a0(2012)\u00a0Novel surface acoustic wave (SAW)-driven closed PDMS flow chamber.\u00a0Microfluidics and Nanofluidics, 12(1-4), pp. 229-235. (doi:10.1007\/s10404-011-0867-5)   […]<\/p>\n","protected":false},"author":1,"featured_media":264,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-63","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured"],"_links":{"self":[{"href":"https:\/\/frankelab.de\/index.php?rest_route=\/wp\/v2\/posts\/63","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/frankelab.de\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/frankelab.de\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/frankelab.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/frankelab.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=63"}],"version-history":[{"count":14,"href":"https:\/\/frankelab.de\/index.php?rest_route=\/wp\/v2\/posts\/63\/revisions"}],"predecessor-version":[{"id":367,"href":"https:\/\/frankelab.de\/index.php?rest_route=\/wp\/v2\/posts\/63\/revisions\/367"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/frankelab.de\/index.php?rest_route=\/wp\/v2\/media\/264"}],"wp:attachment":[{"href":"https:\/\/frankelab.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=63"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/frankelab.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=63"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/frankelab.de\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=63"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}